Cellular Activation Therapy: Reducing the Chronic Complications of Diabetes

Cellular Activation Therapy: Reducing the Chronic Complications of Diabetes

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Description: Cellular Activation Therapy is the only Treatment Proven to Stop and/or Reverse the Chronic Complications of Diabetes. The number of people diagnosed with diabetes worldwide has been consistently on the rise for the last several decades and appears to continue to rise for the foreseeable future. The number of children that are born with Type I diabetes has increased from 1 in every 700 children in the 1970ís to 1 in every 400 today.

Diabetes is perhaps the largest worldwide treatable disease.

 
Author: Bionica Inc. (Fellow) | Visits: 3135 | Page Views: 3215
Domain:  Medicine Category: Therapy Subcategory: Diabetes 
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Short URL: http://medical.wesrch.com/pdfME1LYYNUDUCHB

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Contents:
Cellular Activation Therapy
The ONLY Treatment Proven to Stop, Retard, and/or Reverse the Chronic Complications of Diabetes.
www.Diabetes.Net
Copyright Bionica Inc. All rights reserved. Confidential; no disclosure without permission of Bionica Inc.

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DIABETES a disease of Improper Metabolism
� When food is eaten, the body metabolizes carbohydrates "sugars" and releases insulin from the pancreas directly into the liver. In non-diabetic people, the liver receives insulin in a unique pulsating way which causes the liver to produce enzymes needed for proper metabolism of all foods. This pulsating insulin to the liver is needed for every normal person to activate their cells. Insulin is a primary hormone that performs key functions in maintaining good health, at the cellular level.

Food:

Type 1

� Results from the body's failure to produce insulin, the hormone that "unlocks" the cells of the body, allowing glucose to enter and fuel them. The body of a diabetic is unable to metabolize carbohydrates "sugars" because they do not produce the needed insulin.

Type 2

� Results from improper insulin release to the liver and insulin resistance (a condition where cells fail to properly use insulin). The body's inability to properly metabolize carbohydrates, again, is the core problem. Copyright Bionica Inc. All rights reserved. Confidential; no disclosure without permission of Bionica Inc.

Millions In Need

24 Mil cases of diabetes in USA alone 1 Mil new cases of diabetes each year 24%+ of diabetics, or 4 Mil Need CAT One in three born after 2001, will become diabetic during their life. Native Americans are most inflicted.
The number of people diagnosed with diabetes worldwide has been consistently on the rise for the last several decades and appears to continue to rise for the foreseeable future. The number of children that are born with Type I diabetes has increased from 1 in every 700 children in the 1970's to 1 in every 400 today. Diabetes is perhaps the largest worldwide treatable disease.
Copyright Bionica Inc. All rights reserved. Confidential; no disclosure without permission of Bionica Inc.

Complications of Diabetes
Heart Disease: Stroke:
Heart disease is the leading cause of diabetes related death.

The risk of stroke is 2 to 4 times greater among people with diabetes. 73% of adults with diabetes have high blood pressure.

High Blood Pressure: Blindness:

Diabetic retinopathy is the most common cause of new blindness cases each year. Diabetes is the leading cause of renal disease, accounting for 43% cases.

Kidney Disease: Amputations:

Over 60% of non-traumatic amputations happen among diabetes patients.

Nervous System Disease:

60% to 70% of diabetes patients have mild to severe forms of nervous system damage, depression and malaise.

In addition, many people experience fatigue, sleeping disorders, diabetes related dementia, dental problems, poor wound healing, blackouts, as well as a general lack of energy. Many people with diabetes lose the ability to sense when their glucose levels are dropping. With Cellular Activation Therapysm given by the Bionica MicroDose, Copyright Bionica Inc. All these and other symptoms now slow,rights reserved. Confidential; no disclosure without permission of Bionica Inc. stop and in many cases reverse.

Traditional Treatment Limitations
Insulin Injections:
of diabetes. The most common form of treatment for those who suffer from the effects

Insulin Pumps: Careful Diet:
sensitivity to insulin.

For those want more flexible insulin delivery, these pumps replace shots and also provide a background of insulin, which may be of some help. (These are not anything like the CAT pump.)

Every diabetic knows the difficulty in tightly controlling their daily diet. For Type II diabetes patients, diet usually loses its effectiveness in avoiding symptoms. Some diabetics take oral medications to stimulate production or increase

Oral Medication:

Controlled Exercise Program:

Exercise is another way to help keep the body normal.

The lack of long term effectiveness of all the above methods is known by every person who suffers from diabetes and is widely documented. Hospitals are filled with diabetics who used all of the above methods which eventually loose their effect. Unfortunately, the mortality rate among diabetics has continued to rise over the last decade. Cellular Activation Therapy tm provides the only proven way to impede, stop or reverse the chronic complicationswithout permission of Bionica Inc. Copyright Bionica Inc. All rights reserved. Confidential; no disclosure of diabetes.

The Therapy and Background
Over 18 years of intensive research in leading Universities. Insufficient insulin delivery to the liver plays a central role in the pathophysiology (progression) of diabetes complications. Even with Intensive Insulin therapy (tight control), many diabetic patients will develop the many complications, because tight control does not provide proper metabolism. Poor carbohydrate metabolism results in improper lipid and free fatty acid metabolism, the core problem of diabetes.
Every diabetic will eventually experience one or all of the symptoms of diabetes, some become more ill due to their own genetic and physical makeup. The progression of the disease complications have been irreversible by any other treatment before Cellular Activation Therapy tm.
Copyright Bionica Inc. All rights reserved. Confidential; no disclosure without permission of Bionica Inc.

Cellular Activation Therapy

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Before Activation, there has never been an effective "body wide metabolism" treatment, so physicians were limited to trying to regulate blood glucose (a symptom). Cellular Activation Therapysm is clinically proven to be safe and effective in shifting body wide metabolism toward normal by reawakening enzyme pathways and providing better cellular energy (ATP) production and use. Cellular Activation Therapy sm reestablishes what is normal for healthy human beings. In 2002, it was proven that a normal person's liver receives pulses from the pancreas on a 4 to 6 minute basis. This is what the Bionica MicroDose delivers.
Copyright Bionica Inc. All rights reserved. Confidential; no disclosure without permission of Bionica Inc.

Works on Young Pregnant & Elderly
From young to old, CAT works uniformly to normalize cellular metabolism, and provide constant benefits.

This 7 year old girl was diagnosed at age 2, and was chronically ill with hypoglycemic reactions hypoglycemic unawareness, and many hospitalizations. She has now been on the treatment for 16 years. The pump in the foreground is the Bionica MicroDose with Cellular Activation Therapy programmed into its memory. This girl started on the Bionica MicroDose at age 6.

Now the same girl who was chronically ill, started CAT at age 7; and now age 25 is a healthy mother with 2 healthy children, and pregnant. She is no longer ill, and her only hospitalization since activating has been for childbirth. She has none of her former complications, none of the signs of being a diabetic for 23 years, and has no hypoglycemic reactions.

Copyright Bionica Inc. All rights reserved. Confidential; no disclosure without permission of Bionica Inc.

Annual Costs of Treatment
Outpatient Hospital $20.2 (12%) Office Visits $15.5 (10%) Drugs & DME $14.0 (9%)

Cellular Activation Therapy patients are seldom hospitalized and other symptoms are dramatically reduced.

Home Healthcare $7.4 (4%)

$178 Billion

Inpatient Hospital $115B (63%)

Emergency Room $3.0 (1%) Dental $2.9 (1%)

Copyright Bionica Inc. All rights reserved. Confidential; no disclosure without permission of Bionica Inc.

This hospital cost is almost the same percentage since 1992 !

Savings by Cellular Activation Therapy

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The $115B spent annually for inpatient hospital care is an easy economic reason to support the treatment. Just treating chronically hospitalized patients would justify CAT treatments. Patients that are on CAT are rarely hospitalized for diabetes related complications.

Other areas such as dental, emergency room, etc will also be significantly reduced due to the fact that patients on Cellular Activation Therapy sm do not experience most or any of the side affects of diabetes.

Copyright Bionica Inc. All rights reserved. Confidential; no disclosure without permission of Bionica Inc.

CAT Works With Type 1 & 2
Metabolism is the Problem for BOTH Type I and Type II Diabetics. Cellular Activation Therapy sm works equally well for both Type I and Type II diabetic patients.
After the discovery of insulin, physicians were surprised to learn that insulin alone did not keep diabetic people from developing the horrible complications of diabetes. At that point, the idea of "tight control" of blood glucose was thought to be the answer. This proved wrong. "Tight control" of was then studied in the DCCT, a 10 year NIH study, as well as the UKPDS and other studies. These studies proved that "tight control" is better than not controlling blood glucose, but it does not stop the complications of diabetes. Diabetics do not metabolize properly, resulting in heart, liver, muscle, eye, kidney diseases, and a loss of energy, sleep, sexual function, and all aspects of life are impacted. CAT is the only answer. From the DCCT, it is understood that "while not controlling glucose worsens complications, good control will not keep 25 to 40 % of diabetics from developing overt secondary complications within 10 years." The reality is that all diabetics who are not on Cellular Activation Therapy sm will develop some complications which reduce their lifespan, and complications should be treated with CAT.
Copyright Bionica Inc. All rights reserved. Confidential; no disclosure without permission of Bionica Inc.

Pulses of Insulin
CAT simulates the normal pancreatic delivery of insulin to the liver. Peter Butler, professor of medicine and chair of the division of endocrinology and diabetes, and research fellow Soon Song, received the Endocrine Society's first prize for best clinical paper published in The Journal of Clinical Endocrinology and Metabolism in the year 2002. The paper, "Direct Measurement of Pulsatile Insulin Secretion from the Portal Vein in Human Subjects," reported that insulin is secreted from beta cells in the pancreas almost exclusively in secretory bursts every four to six minutes. The result: very large amplitude oscillations of insulin concentration in the portal vein, which directly perfuses the liver, Butler said. Prior to this study, no one had shown this effect in human beings. Subject was entrained to show agreement between entrained frequency and portal vein insulin oscillations. We conclude that insulin release in the human portal vein occurs at a mean periodicity of 4.4 [plus minus] 0.2 min with a high signal-to-noise ratio (pulse amplitude 660% of basal). This means that the pulses are about 7 times the base levels!
Copyright Bionica Inc. All rights reserved. Confidential; no disclosure without permission of Bionica Inc.

Basic Clinic Structure
Chair Chair Chair Chair

1

2

3

4

1 MD or NP Per Clinic

= 1 QUAD 24 Patients 160,000 Quads Needed
Operating 6 days per week, it will take 160,000 quads in the USA just to treat the extremely ill, and many more for other conditions.

1 RN Per 2 Quads

1 Technician Per Quad

Training, Computerized Treatment Oversight and Bionica Pumps Complete the requirements

Copyright Bionica Inc. All rights reserved. Confidential; no disclosure without permission of Bionica Inc.

Equipment Overview
One 6 hour treatment per week using using the Metabolic Measurement (RQ) machine to monitor metabolism. Patients watch their metabolism return to normal healthy levels. Bionica Pump for Cellular Activation Pulsed Insulin Release.
One of two Models of RQ Machines

Special treatment oversight software ensures proper treatment and tracks results.

The size of a video cassette

Copyright Bionica Inc. All rights reserved. Confidential; no disclosure without permission of Bionica Inc.

Bionica Treatment Process
1 2 3 4 5 6 7 8 9

Measure weight and blood pressure. Check blood sugar level. Medical information reviewed and dosage determined for programming Bionica pump. Small IV inserted in arm or hand. Breathe into RQ machine to measure resting metabolism. Start 1 hour treatment session. Blood sugar level checked and Glucola given as needed. Breathe into RQ machine to measure metabolism levels. Steps 5 � 8 repeated two more times equals 6 hour.
Copyright Bionica Inc. All rights reserved. Confidential; no disclosure without permission of Bionica Inc.

Bionica MicroDose Pump Mimics the Pancreas

The size of a video cassette

As can be seen, the Bionica pump delivers very accurate pulses of insulin, at all levels of infusion. This is required to stimulate the liver and reawaken dormant carbohydrate Copyright Bionica Inc. All rights reserved. Confidential; no disclosure without permission of Bionica Inc. metabolism.

Why Diabetics Need Cellular Activation Therapy

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Notice that the Type 2 diabetic does not have early (first phase) insulin release, as does normal man. This failure to stimulate the liver (and other tissue) is reversed by the Cellular Activation Therapysm. This is why CAT works on Type 1 where there is no insulin release, and Type 2 where Copyright Bionica Inc. All rights reserved. Confidential; no disclosure without permission of Bionica Inc. the insulin is not released in pulses, as it is in normal person.

Cellular Activation Therapy Clinical Results

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This slide shows the importance of early secretion. The Type II diabetic eats, and then shortly thereafter is very hungry again because All rights reserved. Confidential; noof insulin. permission of Bionica Inc. Copyright Bionica Inc. of the high levels disclosure without

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