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Optimal Antibiotics Administration, Medicine, Page 52

Optimal Antibiotics Administration

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Anti-gram positive agents
Vancomycin Fosfomycin
Activity Bactericidal Bactericidal

Spectrum Gram+ve plus MRSA, PRSP Gram+ve plus MRSA,
Enterococcus spp. Enterococcus spp. (! Increased MIC)



Indication Community or nosocomial infection caused by Community or nosocomial infection caused
GP esp. MRSA, MRCNS, PRSP by GP esp. MRSA, MRCNS, PRSP

Antibiotic-associated colitis (oral) Alternative to vancomycin
Precaution Need drug monitoring • Fosfomycin 1g has sodium salt 14.5 mEq
-Patients with unstable renal function • IV only
(either deteriorating or significantly improving)
-Prolonged courses of therapy
-Total trough serum vancomycin concentrations
of 15-20 mg/L for bacteremia endocarditis,
osteomyelitis, meningitis, HAP

 
 
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