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Optimal Antibiotics Administration, Medicine, Page 29

Optimal Antibiotics Administration

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Carbapenem
Ertapenem Imipenem Meropenem Doripenem

Common Phlebitis Phelbitis Phlebitis Headache, insomnia
ADRs GI upset GI upset GI upset GI upset
Rash Rash Rash Elevated liver enz.
Pruritus Pruritus Pruritus Phlebitis

Epilepto- Less 0.5-2% Less Less
genicity Risk factors: renal ds, pre-exisiting
CNS ds or infection, Hx of seizure,
high dose ( ≥ 4 g/d)
Special Lowest collateral Intraabdominal infection US FDA approved for Similar structure to
issues damage to suspected enterococcal Rx of CNS infection meropenem
P. aeruginosa, coninfection
A. baumannii In vitro: MIC90 for
Resist to imipenem P. aeruginosa 2-4
≠ Resist to meropenem, or times lower than
doripenem meropenem, but
limited clinical
data

Not substituted to
older carbapenems

Zhanel GG et al. Drugs 2007;67:1027-52, Chahine EB et al. Am J Health-Syst Pharm
2010;67:2015-24

 

 
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