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Optimal Antibiotics Administration, Medicine, Page 28

Optimal Antibiotics Administration

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Carbapenem
Ertapenem Imipenem Meropenem Doripenem

I/C Community settings Empirical Rx of serious infections in previously multiple ATBs use
intraabdominal or skin Polymicrobial infection
and soft tissue Suspected MDR or ESBL producer, Amp C producer GNR
infection MDR P. aeruginosa infection
Out patient ATB Rx
C/I Relative contraindication to prior hypersensitivity type I to ß lactams

Dose
loading 1 g IV 1 g IV 2 g IV 500 mg (1 g ?)
IV
dose (> 1 g, epileptogenic)

maintenance 1 g IV once daily 500 mg-1 g IV q 6 h 1-2 g IV q 8 h 500 mg IV q 8
h
dose (max 4 g/d) (max 6 g/d) (1 g IV q 8 h
?)

prolonged NA √ √

infusion (3 h) (3 h) (3-4 h)

Renal dose Yes Yes Yes Yes
adjustment
Zhanel GG et al. Drugs 2007;67:1027-52, Chahine EB et al. Am J Health-Syst Pharm
2010;67:2015-24,
Mandell's Priniciples and practice of infectious
disease 7th 2010

 
 
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