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Medical Genomics: Drivers and Potential for Disruptive Change in Personized Medicine, Medicine, Page 8

Medical Genomics: Drivers and Potential for Disruptive Change in Personized Medicine

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Sequence Analyses of Tumor to Guide Therapy
• Genome sequencing and analysis:
- Comparing tumor genome sequence to peripheral blood
lymphocyte (normal, somatic) genome
- Mutation detection
• Transcriptome analysis:
- Digital gene expression profiling of tumor
• Search of DrugBank.ca
- Relate mutations and gene expression data to drugs with
known therapeutic targets and mechanisms of action

“Whole Genome Analysis” requires a variable data package
of genome or exome +/- transcriptome depending upon
clinical indication and diagnostic goals
Steven Jones, CSH Personal
8
Genomes, September, 2010

 
 
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