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Medical Genomics: Drivers and Potential for Disruptive Change in Personized Medicine, Medicine, Page 7

Medical Genomics: Drivers and Potential for Disruptive Change in Personized Medicine

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Case History No. 1
• 78 y/o male, no prior H/O Ca, presented with throat discomfort
- Biopsy revealed papillary adenocarcinoma
• Laser resection and lymph node dissection, 3/21 nodes positive
- 60 Gy adjuvant radiation therapy administered
• 4 months later, PET-CT revealed numerous small bilateral pulmonary mets
- No standard chemo (rare tumor); pathology review indicated 2+ EGFR
• Erlotinib (Tarceva®) started
- Lack of response and tumor progression
• Diagnostic Whole Genome and Transcriptome Analyses




Steven Jones, CSH Personal
7
Genomes, September, 2010