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Semiconductor Biosensing Technology, Medicine, Page 39

Semiconductor Biosensing Technology

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半導体バイオセンシング技術によるDNAシーケンシング
T. Sakata et al., Angew.
Chem. Int. Ed. 45, 2225, (2006).
Factor VII R353Q
参照電極 TGCACGGG
3'-GCCATCACC-5' (9 bases)
5'-ACGTGCCCCGGTAGTGG-3' (17 bases)
VG
Change of threshold voltage, DVT (mV)




A
15CA a A
b
c A

d A T
C C
C G C G
T C A G T T C A T A G T
C T A A G T T A
13 G G C G C
G C G C



11
Si3N4
SiO2
9 Si3N4
SiO2
Si3N4
SiO2
Si3N4
SiO2

Si3N4

SiO2
Si e- e- e- e- e-
Si
GGG
e- e- e- e- e- Si Si
Si
e- e- e- e- e-
e- e- e- e- e-
7
e- e- e- e- e-


ハイブリダイ dCTP dATP
dGTP dTTP
5
ゼーション
T
3 C A繰り返し反応
C G

1
半導体バイオセンシング技術によるDNAシーケンシング
-1

Label-free DNA sequencing based on intrinsic molecular charge

次世代チップ 2010/10/28

 
 
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