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Semiconductor Biosensing Technology, Medicine, Page 38

Semiconductor Biosensing Technology

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Direct Transduction of Extension Reaction into Electrical Signal
Extension reaction T. Sakata and Y. Miyahara, Biosensors & Bioelectronics 22,
1311 (2007).

DNA
polymerase and dNTP
Change of threshold voltage, ΔVT (mV)




25 ◎ Threshold
Voltage (VT)
introduction of DNA polymerase
20
Negative
Charges
(DNA
Molecules)
15

10

+VT(positive)

5

0
0 50 100 150 200 250
time (s)

Charge density change due to extension reaction on gate could be
detected into electrical signal using genetic FET.

次世代チップ 2010/10/28

 

 
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