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Semiconductor Biosensing Technology, Medicine, Page 32

Semiconductor Biosensing Technology

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hOATP-C transporter mutation
Sakata, T. & Miyahara, Y. Analytical Chemistry, 80
(2008), 1493.
~FET Ref. electrode
measurement Oocyte FET Transportocyte FET
Transportocyte FET
Control Wild type Mutant
type
VG


Si3N4 Si3N4 Si3N4
SiO2 SiO2 SiO2
e- e- e- e- e- e- e- e- e- e- e- e- e- e-
e-
Si Si Si


10
injection Estradiol
17b-D-glucuronide
Surface potential (mV)




Wild type (OATP-C*1a)
8 Mutant type (OATP-C*15)
concentration: 20mM
Interface voltage (mV)




Control
Room
Temperature
6

4

約2倍

2


0
0 20 40 60 80
-2 Time (min)

薬剤スクリーニングの可能性

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